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|
Velocity
|
Parameter
|
Model value
|
Literature value
|
References
|
|---|
|
\(V_{\mathrm{AADC}}\)
|
Aromatic amino acid decarboxylase
|
|
\(K_m\)
|
160
|
160
|
[23]
|
|
\(V_{max}\)
|
400
| |
*
|
|
\(V_{\mathrm{CATAB}}\)
|
Catabolism of serotonin
|
|
\(K_m\)
|
95
|
94–95
|
[24, 25]
|
|
\(V_{max}\)
|
4000
| |
*
|
|
\(V_{\mathrm{DRR}}\)
|
Dihydropteridine reductase
|
|
\(K_{bh2}\)
|
100
|
4–754
|
[26, 27]
|
|
\(K_{\mathrm{NADPH}}\)
|
75
|
29–770
|
[28,29,30]
|
|
\(V_{max}^f\)
|
5000
| |
*
|
|
\(K_{bh4}\)
|
10
|
1.1–17
|
[29, 31]
|
|
\(K_{\mathrm{NADP}} \)
|
75
|
29–770
|
[28,29,30]
|
|
\({V_{max}}^b\)
|
3
| |
*
|
|
\(V_{\mathrm{MAT}}\)
|
Vesicular monoamine transporter
|
|
\(K_m\)
|
.2
|
.123–.253
|
[32, 33]
|
|
\(V_{max}\)
|
1230
| |
*
|
|
\(V_{\mathrm{POOL}}\)
|
Linear exchange between trp and pool
|
|
\( k_{topool}\)
|
9
| |
*
|
|
\(k_{frompool} \)
|
0.6
| |
*
|
|
\(V_{\mathrm{SERT}}\)
|
Serotonin transporter
|
|
\(K_m\)
|
.06
|
0.05–1
|
[34]
|
|
\(V_{max}\)
|
250
| |
*
|
|
\(V_{\mathrm{TPH}}\)
|
Tryptophan hydroxylase
|
|
\(K_{trp}\)
|
40
|
40
|
[35]
|
|
\( K_{bh4}\)
|
20
|
20
|
[35]
|
|
\(V_{max} \)
|
278
| |
*
|
|
\(K_i\) (substrate inhibition)
|
1000
|
970
|
[35]
|
|
\(V_{trpin}\)
|
Neutral amino acid transporter
|
|
\(K_m\)
|
330
|
64
|
[36]
|
|
\( V_{max}\)
|
700
| |
*
|
|
\(V_{\mathrm{U2}}\)
|
| |
\(K_m\)
|
.17
|
0.17
|
[37, 38]
|
| |
\(V_{max}\)
|
14
| |
[37, 38]
|
|
Linear diffusion or catabolism
|
| |
\(k^{catab}_{trp}\)
|
2
| |
*
|
| |
\(k^{leak}_{cht}\)
|
1
| |
*
|
| |
\(k_{ght}^{leak}\)
|
1
| |
*
|
| |
\(k^{catab}_{hiaa}\)
|
1
|
.82
|
[39]
|
| |
\(k^{catab}_{pool}\)
|
1
| |
*
|
| |
\(k_{eht}^{rem}\)
|
40
| |
*
|
|
The serotonin autoreceptor
|
| |
\(G_{ht}^{tot}\)
|
10
| |
*
|
| |
\(T_{ht}^{tot}\)
|
10
| |
*
|
| |
\(B_{ht}^{tot}\)
|
10
| |
*
|
| |
\(k_1\)
|
20
| |
*
|
| |
\(k_2\)
|
200
| |
*
|
| |
\(k_3\)
|
30
| |
*
|
| |
\(k_4\)
|
200
| |
*
|
| |
\(k_5\)
|
36000
| |
*
|
| |
\(k_6\)
|
20000
| |
*
|
| |
\(\beta _1\)
|
1
| |
*
|
| |
\(\beta _2\)
|
1
| |
*
|
| |
\(\beta _3\)
|
1
| |
*
|
|
The histamine \(H_3\) receptor
|
| |
\(G_{ha}^{tot}\)
|
1
| |
*
|
| |
\(T_{ht}^{tot}\)
|
60
| |
*
|
| |
\(B_{ht}^{tot}\)
|
10
| |
*
|
| |
\(k_{7}\)
|
4.32
| |
*
|
| |
\(k_{8}\)
|
1.296
| |
*
|
| |
\( k_{9}\)
|
14.4
| |
*
|
| |
\( k_{10}\)
|
25.92
| |
*
|
| |
\( k_{11}\)
|
432
| |
*
|
| |
\( k_{12}\)
|
1440
| |
*
|
|
Other constants (varied in some experiments)
|
| |
NADP
|
26
| |
*
|
| |
NADPH
|
330
| |
*
|
| |
btrp
|
96
| |
*
|
| |
eha
|
1.39
| |
*
|
