Fig. 5

Temporal relation of hippocampal regional discharges. Data collected from thick slices of young mice (7–12 ictal events per slice). All traces collected during slice perfusion with moderately modified ACSF. A Continuous traces collected simultaneously from CA3 and dentate gyrus (DG) areas and illustrated after treatment with a band-pass filter (2–500 Hz). B, C Arrowed events expanded in a wide frequency band (0–1000 Hz). Filled cycles denoted preictal spikes. A solid vertical line denoted the putative onset of CA3 discharge. D A cross correlation plot generated from the discharges in B. X axis of the plot expanded at right. Note CA3 preceding DG signals by ~ 25 ms in the time lag of maximum correlation. E–H, CA3 and CA1 discharges similarly illustrated and analyzed as above. Note CA3 preceding CA1 signals by ~ 10 ms in the time lag of maximum correlation. I Onset time lags measured from corresponding CA3-DG (3 slices) or CA3-CA1 discharges (4 slices). J Time lags of maximum correlation in cross correlation plots. Positive measures refer CA3 preceding DG or CA1 signals. Box plots presented in I, J, and interquartile range abbreviated as IQR